Will Manidis is the CEO and founder of ScienceIO, which builds data solutions for health care. He was previously a managing partner at Dorm Room Fund, and a Thiel Fellow.
Auren and Will discuss American dynamism and the future of knowledge work. Will breaks down his view that technology has not improved our lives as much as it should have. He explains how the nature of platform shifts have accelerated tech earnings over the last decade, but kept actual progress low.
Will and Auren also do a deep dive on healthcare: why it’s so expensive, why healthcare data is so difficult to work with, and what can be changed. Will emphasizes the need for more usable healthcare data and breaks down how operational workflows consume most of the healthcare dollars spent in the US.
They also discuss Will’s practical advice for young founders (as a founder and former Thiel fellow), his early work on classical Greek and Latin, and why everyone should believe in demons.
You can find Auren Hoffman on Twitter at @auren and Will Manidis on Twitter at @WillManidis.
Esther Dyson is an investor, journalist, author, and philanthropist. She is the executive founder of Wellville, a nonprofit project focused on improving equitable wellbeing.
Esther and Auren discuss the structural problems that drive poor wellbeing across modern society. They dive into potential solutions ranging from improving parenting to the role of government.
They also discuss how untapped data about people can potentially revolutionize health and wellness.
You can find Auren Hoffman (CEO of SafeGraph) on Twitter at @auren and Esther Dyson at @edyson
David is a co-founder and partner at Craft Ventures, one of the foremost SaaS VCs. He was the former COO at Paypal and he’s invested in over 20 unicorns, including AirBnB, Facebook, Palantir, Uber, and SpaceX.
David and Auren discuss the state of SaaS in 2023 and consider how layoffs, seat contraction, and the broader macro environment could affect the ecosystem this year. David shares some advice on how companies should be positioning themselves to weather the downturn. They also talk about bubbles and cycles in tech, how to spot stand-out founders early, and which analysts have the best record on foreign policy.
You can find Auren Hoffman on Twitter at @auren and David Sacks on Twitter at @DavidSacks